Koshland: The First Year

The Goldbeter-Koshland Switch in the First-Order Region and Its Response to Dynamic Disorder

In their classical work (Proc. Natl. Acad. Sci. USA, 1981, 78:6840-6844), Goldbeter and Koshland mathematically analyzed a reversible covalent modification system which is highly sensitive to the concentration of effectors. Its signal-response curve appears sigmoidal, constituting a biochemical switch. However, the switch behavior only emerges in the 'zero-order region', i.e. when the signal mo...

Lasker∼Koshland to Genetics Pioneer

The 2014 Lasker∼Koshland Special Achievement Award will be presented to Mary-Claire King, a pioneer and visionary who revolutionized the use of genetics to identify disease genes, provide insights into human evolution, and champion human rights causes.

The EngD First Year Report

The First Year in School

This is a delightful and very valuable book. It considers the whole personality of the five year old child in the first year in school, with affection and understanding, but without sentimentality. The author has a definite ideal of what school life ought to be for children. She condemns very outspokenly what school too often offers the five year old. "Many classrooms today are slums." Neverthe...

Analysis of Goldbeter-Koshland Switch Using the Chemical Master Equation

The chemical master equation is considered as an accurate description of general chemical systems, and especially so for modeling gene regulatory networks and protein-protein interaction networks. This paper examines some “off-the-shelf” numerical approaches to solve the chemical master equation for the Goldbeter-Koshland switch on both sequential and parallel machines. The numerical results sh...